Generics: Paracetamol + Caffeine.
Dosage Form: Tablet.
This is a combination of acetaminophen and caffeine. Paracetamol has analgesic and antipyretic properties, and its anti-inflammatory activity is weak. Caffeine is an alkaloid, a derivative of xanthine, similar to theophylline. Through the intermolecular association with paracetamol, caffeine increases the solubility and transmembrane permeability of paracetamol. In addition, caffeine increases pain threshold and pain tolerance. Caffeine also has the inherent power to increase the tone of blood vessels in the brain, which provides another benefit for the treatment of migraines and headaches.
Paracetamol is suitable for fever, common cold and flu, headache, toothache, earache, body pain, myalgia, neuralgia, dysmenorrhea, sprain, colic, back pain, postoperative pain, postpartum pain, inflammatory pain and pain in children after vaccination. It is also suitable for rheumatic pain and osteoarthritis and joint stiffness.
3 to 4 times daily.
- Children 3-12 months: 60-120 mg,4 times daily.
- Children 1-5 years: 125-250 mg 4 times daily.
- Children 6-12 years: 250-500 mg 4 times daily.
- Adults & children over 12 years: 0.5-1 gm 4 times daily.
- Paediatric Drop:
Children Upto 3 months: 0.5 ml (40 mg)
- 4 to 11 months: 1.0 ml (80 mg)
- 7 to 2 years: 1.5 ml (120 mg). Do not exceed more than 5 dose daily for a maximum of 5 days.
Paracetamol tablet with actizorb technology: It dissolves up to five times faster than standard Paracetamol tablets. It is a fast acting and safe analgesic with marked antipyretic property. It is specially suitable for patients who, for any reason, can not tolerate aspirin or other analgesics.
Adults and children (aged 12 years and over): Take 1 to 2 Tablets every four to six hours as needed. Do not take more than 8 caplets in 24 hours.
Children (7 to 11 years): Take ½-1 Tablet every four to six hours as needed. Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years.
Route of administration: Orally.
Patients taking barbiturates, tricyclic antidepressants, and alcohol may have a reduced ability to metabolize large doses of paracetamol. Alcohol can increase liver toxicity from acetaminophen overdose. Long-term use of anticonvulsants or oral steroid contraceptives can induce liver enzymes and may prevent therapeutic levels of paracetamol from being achieved by increasing metabolism or first-pass clearance.
It is contraindicated in known hypersensitivity to Paracetamol.
The side effects of paracetamol are usually mild, although hematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Occasionally, pancreatitis, skin rashes, and other allergic reactions occur.
Pregnancy & Lactation
Pregnancy Category B regulated by the United States Food and Drug Administration (USFDA). The drug should be used during pregnancy only when clearly necessary.
Precautions & Warnings:
Paracetamol should be used with caution in patients with renal or liver damage. Patients taking other drugs that affect the liver should use paracetamol with caution.
Non opioid analgesics
Keep in a dry place away from light and heat. Keep out of the reach of children.
Manufactured by: Square Pharmaceuticals Ltd.