Dosage Form: Inhaler.
Bronchospasm: Salbutamol Inhaler is indicated for the treatment or prevention of bronchospasm in bronchial asthma and for the treatment of reversible airway obstruction associated with bronchitis and emphysema.
Exercise-Induced Bronchospasm: Salbutamol Inhaler may be used to relieve attacks of acute dyspnoea and may also be taken prophylactically before exertion or to prevent exercise-induced asthma.
Salbutamol is a selective agonist of the 2-adrenoceptor. It works on the 2-adrenoceptors of bronchial smooth muscle at therapeutic levels, but has little or no effect on the 1-adrenoceptors of cardiac muscle. In reversible airway blockage, salbutamol produces short-acting (4-6 hours) bronchodilation with a rapid onset (within 5 minutes). It also inhibits the release of bronchoconstrictor mediators such as histamine, neutrophil chemotactic factor (NCF), and prostaglandin D2 via acting as an anti-inflammatory on mast cells.
Four times in daily.
Administer Salbutamol Inhaler by oral inhalation only. Shake Salbutamol Inhaler well before each spray.
For relief of acute episodes of bronchospasm:
- Adults: 1 or 2 puffs as necessary. The maximum dose is up to 8 puffs in 24 hours.
- Children: Half the adult dose.
To prevent allergen-or exercise-induced bronchospasm:
- Adults: 2 puffs 15 minutes prior to exercise or exposure to the allergen. The maximum dose is 2 puffs, up to 4 times a day.
- Children: Half the adult dose.
- Adults: Up to 200 mcg (2 puffs) four times daily.
- Children: Up to 200 mcg (2 puffs) four times daily.
Route of administration: Orally.
Salbutamol and non-selective beta-blocking drugs such as propranolol should generally not be prescribed together. Potentially serious hypokalaemia may result from β2-agonist therapy. Particular caution is advised in acute severe asthma as this effect may be potentiated by concomitant treatment with xanthine derivatives, steroids, diuretics, and by hypoxia. It is recommended that serum potassium levels are monitored in such situations.
Salbutamol inhaler is contraindicated in patients with a history of hypersensitivity to salbutamol or any other components of Salbutamol inhaler.
Salbutamol is easily tolerated by most people. During inhalation, just a few adverse effects have been recorded. Tremors, anxiety, muscle cramps, headache, palpitation, a compensatory slight rise in heart rate, cardiac arrhythmias (including atrial fibrillation, supraventricular tachycardia, and extrasystoles), and tachycardia are all possible symptoms. Salbutamol inhalation can cause mouth and throat discomfort.
Pregnancy & Lactation:
Pregnancy Classification C. In pregnant women, there are no sufficient and well-controlled studies using salbutamol inhaler or salbutamol sulfate. During pregnancy, this inhaler should only be used if the possible benefit outweighs the potential risk to the fetus. The components of the Salbutamol inhaler are not known to be excreted in human milk. When administering this inhaler to a nursing mother, exercise caution.
Precautions & Warnings:
Paradoxical Bronchospasm: Inhaled salbutamol sulfate can cause life-threatening paradoxical bronchospasm. If paradoxical bronchospasm occurs, the Salbutamol inhaler should be stopped right away and another treatment plan implemented. When it comes to inhaled formulations, it’s important to remember that paradoxical bronchospasm frequently develops after the first use of a new canister.
Cardiovascular Effects: As with all other 2-adrenergic agonists, salbutamol inhaler might cause clinically significant cardiovascular effects in some people, such as changes in pulse rate or blood pressure. Salbutamol inhaler may need to be stopped if such side effects arise.
Short-acting selective & β2-adrenoceptor stimulants
Keep in a dry place, away from light and heat. Keep out of the reach of children.
Manufactured by: Beximco Pharmaceuticals Ltd.