Clotrim Cream

Clotrimazole 1%
The ACME Laboratories Ltd.

৳ 35.00

1 Tube of 10 gm

Dermatomycoses due to candida, trichophyton, moulds and other fungi, skin diseases showing superinfections with these fungi e.g. inter digital mycoses, paronychia, candida vulvitis, balanitis, pityriasis versicolor and erythrasma. Clotrimazole is also active against certain gram-positive bacteria especially Staphylococci and Tricomonas. Clotrimazole alters the permeability of fungal cell walls by interfering with cell wall lipids.



Dosage Form: Cream.


  • All dermatomycoses due to dermatophytes (e.g.Trichophyton species).
  • All dermatomycoses due to yeasts (Candida species).
  • Dermatomycoses due to moulds and other fungi.
  • Skin diseases showing superinfections with these fungi.

Some examples of skin infections included in above points are interdigital mycoses (e.g. athlete’s foot), paronychias (associated with nail mycoses), mycoses in skin folds, Candida vulvitis, Candida balanitis, Pityriasis versicolor, erythrasma.

Clotrimazole acts primarily by damaging the permeability barrier in the cell membrane of fungi. Clotrimazole causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. If ergosterol synthesis is either completely or partially inhibited, the cell is no longer able to construct an intact and functional cell membrane. Because ergosterol directly promotes the growth of fungal cells in a hormone‐like fashion, rapid onset of the above events leads to dose-dependent inhibition of fungal growth.

Though decreased ergosterol, due to the inhibition of lanosterol 14-demethylase (also known as CYP51) is accepted to be primarily responsible for the antimycotic properties of clotrimazole, this drug also shows other pharmacological effects. These include the inhibition of sarcoplasmic reticulum Ca2+ ATPase, depletion of intracellular calcium, and blocking of calcium‐dependent potassium channels and voltage‐dependent calcium channels. The action of clotrimazole on these targets accounts for other effects of this drug that are separate from its antimycotic activities.

Dosage guideline:
Clotrimazole Cream: This should be thinly applied 2-3 times daily to the infected sites and rubbed in. On account of the excellent efficacy, a small amount of cream is usually sufficient for an area about the size of the palm. For the treatment to become a complete success, reliable and sufficiently long-time application of Clotrimazole Cream is important. The duration of treatment varies; it depends among other factors on the extent and localization of the disease.

Recommended duration of treatment-

  • Dermatomycoses: 3-4 weeks
  • Candida vulvitis and Candida balanitis: 1-2 weeks
  • Erythrasma and Pityriasis Versicolor: 3 weeks (approximately)

In fungal infection of the feet, to prevent relapse, treatment should be continued for about 2 weeks beyond the disappearance of all signs of disease. After washing, the feet should be thoroughly dried (particularly spaces between the toes). Clotrimazole Cream is odorless, can be washed off and does not stain clothing.

Route of administration: Topically.

No information is available.

Hypersensitivity to Clotrimazole.

Side Effects:
When applied topically, clotrimazole is well tolerated. When applied externally, no systemic effects were observed. In rare cases, local irritation or burning may occur, but these symptoms are not considered harmful.

Pregnancy & Lactation:
It is recommended that Clotrimazole should be used in pregnancy only when considered necessary by the physician.

 Precautions & Warnings:
Before you use Afun Cream, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic any of the following substances: cetostearyl alcohol.

Therapeutic Class:
Drugs for subcutaneous and mycoses, Topical Antifungal preparations

Storage Conditions:
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.

Manufactured by: ACME Laboratories Ltd.