Comprid XR 60 Tablet

Gliclazide 60mg
Square Pharmaceuticals Ltd.

৳ 120.00

1 Strip of 10 tablets

Patients with maturity-onset diabetes mellitus (NIDDM) who require an oral hypoglycaemic medication should use gliclazide. Gliclazide is a sulfonylurea of the second generation with hypoglycemic and possibly hematological effects. It reduces hepatic glucose production while stimulating insulin release from pancreatic -cells by promoting Ca+2 transport across the -cell membranes.



Dosage Form: Tablet.

Gliclazide is a medicine that reduces blood sugar levels (oral antidiabetic medicine belonging to the sulphonylurea group). Gliclazide is used in a certain form of diabetes (type 2 diabetes Mellitus) in adults, when diet, exercise and weight loss alone do not have an adequate effect on keeping blood sugar at the correct level.

Gliclazide is a second generation sulfonylurea drug that has hypoglycaemic and potentially useful hematological properties. It stimulates the release of insulin from pancreatic β-cells by facilitating Ca+2  transport across the β-cell membranes and decreases hepatic glucose output.

Dosage guideline:
The normal starting dose is 40 to 80 mg per day as a film-coated tablet. When needed, the dosage can be raised to 320 mg daily in split doses. The medication should be taken before a meal. Because Gliclazide is contraindicated in juvenile-onset diabetes, it is not used in children.

Gliclazide 30 mg is usually taken as 1 to 4 tablets per day, whereas Gliclazide 60 mg is used as 1 to 2 tablets per day as a single dose. It is suggested that the medication be taken first thing in the morning. It is best to take this medication before breakfast in order to avoid or reduce the risk of stomach problems.

Route of administration: Orally.

Aspirin, NSAIDs, Phenylbutazone, Clofibrate, Sulfonamide, Cimetidine, Imidazole antifungal medications, and Monoamine Oxidase inhibitors may enhance Gliclazide’s hypoglycaemic effects. Rifampin, Barbiturates, Phenytoin, Thiazide diuretics, Diazoxide, Glucocorticoids, Estrogens, Sympathomimetic medications, and Alcohol may decrease the hypoglycaemic impact of Gliclazide.

Comprid should not be used in the following situations:

  • Juvenile-onset (type-1) diabetes
  • Diabetes associated with Ketosis
  • Diabetic patients undergoing surgery, after severe injury or during infection
  • Patients having hypersensitivity for sulfonylurea group of drugs
  • Pregnant women and breastfeeding mothers
  • Hepatic insufficiency

Side Effects:
Hypoglycemia can occur in the presence of other diseases such as hepatic and renal dysfunction, starvation, and alcohol abuse. Headaches, gastrointestinal disturbances, nausea, dizziness, and skin responses such as rash, pruritus, and erythema are all possible side effects.

Pregnancy & Lactation:
Pregnant women should avoid using Comprid. It should not be used by a woman who is breastfeeding.

 Precautions & Warnings:
In individuals with hepatic impairment, Comprid should be taken with caution. Comprid should not be taken if there is clear evidence of liver illness. Because Comprid is thoroughly metabolized, it can be administered safely in individuals with renal failure. Comprid has a lower risk of hypoglycemia than the other sulfonylurea medications.

Therapeutic Class:

Storage Conditions:
Store below 30°C and away from light in a cool, dry area.

Manufactured by: Square Pharmaceuticals Ltd.