Description
Generics: Dicycloverine Hydrochloride
Dosage Form: Syrup
Indications:
Dicycloverine is used to treat the following conditions:
- Irritable bowel syndrome/functional bowel syndrome
- Urinary incontinence as a result of a weakened detrusor muscle
- Colic in children
- spasms in the gastrointestinal tract
- Irritable bowel syndrome
- Diverticulitis
- Colic in the abdomen
Pharmacology:
Dicycloverine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent. Chemically, it is [Bicyclohexyl-]1-carboxylic acid, 2-(diethylammo) ethyl ester, hydrochloride. Dicycloverine relieves smooth muscle spasm of the gastrointestinal tract. Dicycloverine HCl Injection is a sterile, pyrogen-free, aqueous solution for intramuscular injection (Not For Intravenous Use). It works at specific receptors, called cholinergic (or muscarinic) receptors, located on the involuntary muscle in the walls of the gut. By binding to these receptors dicycloverine prevents certain chemicals produced by the body from interacting with these receptors. This causes the gut muscle to relax, relieving the pain of colic produced by gut muscle contraction and spasm.
Dosage guideline:
Three times a day.
For oral dosage forms:
- Adults:10 to 20 mg three times a day.
- Children over 6 months of age: 5 to 10 mg three times a day.
For injectable dosage form:
- Adults: Intramuscular injection. Not for intravenous use. The recommended intramuscular dose is 80 mg daily (in 4 equally divided doses).
Oral dicycloverine Hydrochloride should be started as soon as possible and the intramuscular form should not be used for periods longer than 1 or 2 days.
Children: Dose must be determined by the doctor.
Route of administration: Orally.
Side Effects:
Insomnia, mydriasis, cycloplegia, increased ocular tension, urinary hesitancy, palpitations, dyspnea.
Pregnancy & Lactation:
Pregnancy Classification B. In animal studies, dicycloverine was neither teratogenic nor embryocidal. It, like other medications, should only be taken during pregnancy if absolutely necessary. There is no information on the drug’s release into breast milk. In the case of a lactating mother, dicycloverine should be administered with caution.
 Precautions & Warnings:
Patients with autonomic neuropathy, hepatic or renal disease, ulcerative colitis, coronary heart disease, congestive heart failure, cardiac tachyarrhythmia, hiatal hernia, or known or suspected prostatic enlargement should use this medication with caution.
Therapeutic Class:
Anticholinergics (antimuscarinics)/ Anti-spasmodics
Storage Conditions:
Anticholinergics (antimuscarinics)/ Anti-spasmodics
Manufactured by: Incepta Pharmaceuticals Ltd.
